abstract：BACKGROUND:The oral dual endothelin (ET) antagonist bosentan has been established as a cornerstone in the treatment of pulmonary arterial hypertension (PAH). ET is believed to be a key pathogenic mediator in systemic sclerosis (scleroderma, SSc), causing fibrotic, hypertrophic and inflammatory processes. PAH is one of ...

journal_title：European journal of clinical investigation

authors： Ahmadi-Simab K,Hellmich B,Gross WL

更新日期：2006-09-01 00:00:00

abstract：:Fabry disease is an X-linked lysosomal storage disorder characterized by multi-organ dysfunction, including hearing loss - mainly sensorineural. The recent introduction of enzyme replacement therapy (ERT) has resulted in improvements in renal and cardiac function, pain and quality of life. One study has also suggested...

journal_title：European journal of clinical investigation

authors： Hajioff D,Hegemann S,Conti G,Beck M,Sunder-Plassmann G,Widmer U,Mehta A,Keilmann A

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:In the 13C-octanoate breath test, the shape of the 13CO2 excretion curve in the ascending portion reflects a pattern of gastric emptying (GE). Recent scintigraphic studies have revealed an overall delay in solid GE in fertile women compared with men. However, it remains unknown whether women have a different...

journal_title：European journal of clinical investigation

authors： Sanaka M,Yamamoto T,Anjiki H,Osaki Y,Kuyama Y

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Buerger's disease (BD) is a segmental occlusive vascular disease. The aim of this study was to detect functional changes in brachial artery and asymptomatic morphological changes in extra-cranial carotid arteries not affected by the disease process and to assess markers of inflammation and endothelial damage...

journal_title：European journal of clinical investigation

authors： Joras M,Poredos P,Fras Z

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Complement fragment C5a and neutrophils have been implicated in the pathogenesis of renal disease and C5a has also been shown to delay apoptosis of human neutrophils via a transcription-independent pathway. However, transcription-dependent pathways have not been well described. The present study examined whe...

journal_title：European journal of clinical investigation

authors： Perianayagam MC,Madias NE,Pereira BJ,Jaber BL

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the progressive failure of hypoglycaemia counterregulation in long-standing type 1 diabetes are poorly understood. Increased brain glucose uptake during hypoglycaemia or alterations of brain energy metabolism could effect glucose sensing by the brain and thus contribute to hypo...

journal_title：European journal of clinical investigation

authors： Bischof MG,Brehm A,Bernroider E,Krssák M,Mlynárik V,Krebs M,Roden M

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Lipoprotein(a) [Lp(a)] is an important cardiovascular risk factor in the general population. However, prospective data on the vascular risk conferred by Lp(a) in patients with diabetes mellitus are scarce and controversial. It is not known whether the diabetic state affects the association of Lp(a) with vasc...

journal_title：European journal of clinical investigation

authors： Saely CH,Koch L,Schmid F,Marte T,Aczel S,Langer P,Hoefle G,Drexel H

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:We have investigated the potential for using antisense technology as a means of delivering treatment for acute myeloblastic leukaemia (FAB-M2) by gene therapy. MATERIALS AND METHODS:A test recombinant adenovirus vector was constructed containing human c-myc antisense fragments to study the effects of alteri...

journal_title：European journal of clinical investigation

authors： Chen JP,Chen L,Leek J,Lin C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Although both strength training (ST) and endurance training (ET) seem to be beneficial in type 2 diabetes mellitus (T2D), little is known about post-exercise glucose profiles. The objective of the study was to report changes in blood glucose (BG) values after a 4-month ET and ST programme now that a device f...

journal_title：European journal of clinical investigation

authors： Cauza E,Hanusch-Enserer U,Strasser B,Kostner K,Dunky A,Haber P

更新日期：2005-12-01 00:00:00

abstract：:Anaemia is a common condition among pre-end-stage renal disease (pre-ESRD) patients with chronic kidney disease (CKD). Indeed, data from clinical studies indicate that anaemia may be present in as many as two-thirds of such patients. Use of recombinant human erythropoietin (EPO) provides an effective means of correcti...

journal_title：European journal of clinical investigation

authors： McClellan WM,Jurkovitz C,Abramson J

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Mortality from prostate cancer remains a significant problem with current treatment(s), with an expected 30 350 deaths from prostate cancer in 2005. Long-acting natriuretic peptide, vessel dilator, kaliuretic peptide and atrial natriuretic peptide have significant anticancer effects in breast and pancreatic ...

journal_title：European journal of clinical investigation

authors： Vesely BA,Alli AA,Song SJ,Gower WR Jr,Sanchez-Ramos J,Vesely DL

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Augmentation index (AIx) is a measure of arterial wave reflection, providing information on the workload of the heart. and is a possible marker for cardiovascular disease risk. The relation of alcohol consumption with cardiovascular disease (CVD) risk is U-shaped with a protective effect of moderate alcohol ...

journal_title：European journal of clinical investigation

authors： van Trijp MJ,Bos WJ,van der Schouw YT,Muller M,Grobbee DE,Bots ML

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To investigate alterations in endothelial nitric oxide synthase and inducible nitric oxide synthase mRNA expressions and nitric oxide release in the myocardium during ischaemia/reperfusion and determine whether these changes are ischaemic and/or reperfusion dependent. MATERIALS AND METHODS:Isolated rat heart...

journal_title：European journal of clinical investigation

authors： Pevni D,Frolkis I,Shapira I,Schwartz D,Schwartz IF,Chernichovski T,Lev-Ran O,Sharony R,Uretzky G

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Diets and Omega-3 polyunsaturated fatty acids have been considered as important factors to reduce the risk of cardiovascular and inflammatory diseases, but there are few details on the effects on healthy subjects. The aim of the present study was to examine the variation of several physiological parameters i...

journal_title：European journal of clinical investigation

authors： Fontani G,Corradeschi F,Felici A,Alfatti F,Bugarini R,Fiaschi AI,Cerretani D,Montorfano G,Rizzo AM,Berra B

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Four peptide hormones of a family of six hormones, i.e. atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-natriuretic peptide (CNP), long acting natriuretic peptide (LANP), vessel dilator and kaliuretic peptide, significantly decrease the number of adenocarcinoma cells in culture. The pres...

journal_title：European journal of clinical investigation

authors： Vesely BA,Song S,Sanchez-Ramos J,Fitz SR,Alli AA,Solivan SM,Gower WR Jr,Vesely DL

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Several clinical trials have suggested that a metabolic cocktail of glucose-insulin-potassium (GIK) decreases mortality rates in patients with acute myocardial infarction (AMI). It has also been reported that Fas-mediated apoptosis plays an important role in ischaemic/reperfusion injury in the rat model. Thi...

journal_title：European journal of clinical investigation

authors： Zhang L,Zhang L,Li YH,Zhang HY,Chen ML,Gao MM,Hu AH,Yang HS,Yang HS

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Following cisplatin-based chemotherapy, survivors of testicular cancer have a high prevalence of cardiovascular risk factors and an increased risk of cardiovascular disease. Cardiac function has not been extensively studied and no comparisons have been made with men from the general population. DESIGN:Left ...

journal_title：European journal of clinical investigation

authors： Nuver J,Smit AJ,Sleijfer DT,van Gessel AI,van Roon AM,van der Meer J,van den Berg MP,Hoekstra HJ,Sluiter WJ,Gietema JA

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) of marine origin are well recognized. Because of the shortness of marine resources vegetable oils are increasingly used in fish farming. The effects on human health of fish fed on vegetable oils are largely unknown. METHODS:In a dou...

journal_title：European journal of clinical investigation

authors： Seierstad SL,Seljeflot I,Johansen O,Hansen R,Haugen M,Rosenlund G,Frøyland L,Arnesen H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:In obese subjects, chronic low-grade inflammation contributes to an increased risk of metabolic abnormalities, which are reversed by weight loss. Sustained weight loss, however, is difficult to achieve and more insight into dietary approaches on anti-inflammatory responses in obese subjects is needed. In thi...

journal_title：European journal of clinical investigation

authors： Jellema A,Plat J,Mensink RP

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:In model biles, cholesterol crystallization (an important factor in gallstone formation) mainly depends on phospholipid/bile salt ratios with characteristic sequences of plate-like (monohydrate) vs. non-plate-like (presumed anhydrous: arcs, needles, tubules, spirals) cholesterol crystals. We now investigate ...

journal_title：European journal of clinical investigation

authors： Venneman NG,Portincasa P,Vanberge-Henegouwen GP,van Erpecum KJ

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Recently, a new mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) encoding gene was first described (1793G > A). Only few reports have studied the prevalence of this polymorphism, especially in combination with other MTHFR mutations (677C > T, 1298A > C). METHODS:We cross-sectionally identifi...

journal_title：European journal of clinical investigation

authors： Winkelmayer WC,Sunder-Plassmann G,Huber A,Födinger M

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Humming greatly increases nasal nitric oxide (NO) in healthy people by causing a rapid washout of NO from the sinuses. This increase is abolished in patients with complete sinus ostial obstruction. OBJECTIVE:Allergic rhinitis is a risk factor for development of sinusitis and we wanted to study whether nasal...

journal_title：European journal of clinical investigation

authors： Maniscalco M,Sofia M,Weitzberg E,De Laurentiis G,Stanziola A,Rossillo V,Lundberg JO

更新日期：2004-08-01 00:00:00

abstract：:Microparticles are small membrane vesicles that are released from cells upon activation or during apoptosis. Cellular microparticles in body fluids constitute a heterogeneous population, differing in cellular origin, numbers, size, antigenic composition and functional properties. Microparticles support coagulation by ...

journal_title：European journal of clinical investigation

authors： Diamant M,Tushuizen ME,Sturk A,Nieuwland R

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Excess of cardiovascular risk among patients with chronic inflammatory diseases has been attributed to increased arterial stiffness. Hypercholesterolaemia has been demonstrated to promote a low-grade inflammatory status. The objective of the present study was to define, in hypercholesterolaemia, the influenc...

journal_title：European journal of clinical investigation

authors： Pirro M,Schillaci G,Savarese G,Gemelli F,Vaudo G,Siepi D,Bagaglia F,Mannarino E

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIMS:Nitric oxide synthase (NOS) 3-deficient (NOS-3 KO) mice have an increased systemic arterial pressure but develop portal hypertension to the same extent as wildtype (WT) mice. We hypothesized that other vasodilators in the portal circulation compensate for the lack in NOS-3 activity. We used quantitative...

journal_title：European journal of clinical investigation

authors： Biecker E,Sägesser H,Reichen J

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, which can relapse in many patients after antithyroid drug treatment withdrawal. Several studies have been performed to predict the clinical course of GD in patients treated with antithyroid drugs, without conclusive results. The...

journal_title：European journal of clinical investigation

authors： Orunesu E,Bagnasco M,Salmaso C,Altrinetti V,Bernasconi D,Del Monte P,Pesce G,Marugo M,Mela GS

更新日期：2004-03-01 00:00:00

abstract：:Increased cardiovascular mortality is an unresolved problem in patients with chronic renal failure. Cardiac hypertrophy is observed in the majority of patients with chronic renal failure undergoing haemodialysis. However, the mechanisms, including signal transduction pathways, responsible for cardiac hypertrophy in re...

journal_title：European journal of clinical investigation

authors： Takahashi H,Takeishi Y,Miyamoto T,Shishido T,Arimoto T,Konta T,Miyashita T,Ito M,Kubota I

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE), a rare heritable disorder caused by mutations of the ABCC6 gene, is characterized by fragmentation and mineralization of elastic fibres. We determined the extent of degradation of elastin by measuring and comparing the amount of desmosines in plasma and urine of PXE patients, ...

journal_title：European journal of clinical investigation

authors： Annovazzi L,Viglio S,Gheduzzi D,Pasquali-Ronchetti I,Zanone C,Cetta G,Iadarola P

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Glucocorticosteroids are effective in the treatment of allergic rhinitis, a disease characterized by a variety of symptoms, e.g. rhinorrhea and itching. The time course of symptomatic relief for allergic rhinitis by steroids has not been examined in detail to date, although the onset of steroid action is one...

journal_title：European journal of clinical investigation

authors： Tillmann HC,Stuck BA,Feuring M,Rossol-Haseroth K,Tran BM,Lösel R,Schmidt BM,Hörmann K,Wehling M,Schultz A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Reduced aortic distensibility predicts cardiovascular mortality in patients with type 2 diabetes and impaired glucose tolerance. Cardiac autonomic neuropathy is common in subjects with diabetes. However, the relationship between the elastic properties of the aorta and autonomic neuropathy has not been studie...

journal_title：European journal of clinical investigation

authors： Tentolouris N,Liatis S,Moyssakis I,Tsapogas P,Psallas M,Diakoumopoulou E,Voteas V,Katsilambros N

更新日期：2003-12-01 00:00:00

abstract：:The ATP-binding cassette transporter P-glycoprotein is now recognized as an important determinant for disposition of multiple drugs. The use of P-glycoprotein-expressing cell lines, the generation of P-glycoprotein knockout mice as well as studies in animals and humans contributed to a better understanding on the role...

journal_title：European journal of clinical investigation

authors： Fromm MF

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Renal cyclooxygenases (COX) produce the prostaglandins (PG) E2, I2 and thromboxane (TxA2), which interact with distinct G protein-coupled receptors. We investigated the expression of the three EP receptors EP2, EP3 and EP4 and the receptors for PGI2 (IP) and TxA2 (TP) in rats with passive Heymann nephritis (...

journal_title：European journal of clinical investigation

authors： Waldner C,Heise G,Schrör K,Heering P

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Angiogenesis is essential for tumour growth and metastasis, and is coordinated by several classes of growth factors mediating their effect through receptors linked, in turn, to tyrosine kinase. These growth factors include angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and vascular endothelial growth factor ...

journal_title：European journal of clinical investigation

authors： Caine GJ,Blann AD,Stonelake PS,Ryan P,Lip GY

更新日期：2003-10-01 00:00:00

abstract：:In contrast to bile salts, which undergo a highly efficient enterohepatic circulation with multiple regulatory and physiologic functions, glucuronic acid conjugates of bilirubin are biliary excretory molecules that in health do not have a continuing biologic life. Intestinal absorptive cells are devoid of recapture tr...

journal_title：European journal of clinical investigation

authors： Vítek L,Carey MC

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Different time-concentration profiles of plasma insulin following insulin modification of a frequently sampled intravenous glucose-tolerance-test (FSIVGTT) were observed in a study investigating maternal metabolism and fetal macrosomia. We aimed to investigate whether these differences were related to the vo...

journal_title：European journal of clinical investigation

authors： Jolly MC,Hovorka R,Godsland I,Amin R,Lawrence N,Anyaoku V,Johnston D,Robinson S

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Inflammation and immune activation appear to be important in the pathogenesis of coronary heart disease (CHD). Cytokine interferon-gamma, which is released during cell-mediated immune responses, induces indoleamine (2,3)-dioxygenase (IDO), an enzyme degrading tryptophan to kynurenine. Therefore, immune stimu...

journal_title：European journal of clinical investigation

authors： Wirleitner B,Rudzite V,Neurauter G,Murr C,Kalnins U,Erglis A,Trusinskis K,Fuchs D

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Variation of percentageCD4+ T cells may accurately reflects the kinetics of a comprehensive immune recovery independently of the antiretroviral (ART) regimen. To test this we have investigated the relationship among peripheral blood T-cell subsets with the variation of percentageCD4+ T cells during follow up...

journal_title：European journal of clinical investigation

authors： Resino S,Bellón JM,Gurbindo D,León JA,Muñoz-Fernández MA

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:Complement-mediated tubular injury may play an important role in the progression of renal diseases. C3d is a presumed marker of complement activation. Its precursor C3dg has been detected in the urine of patients with membranous nephropathy. However, little is known of the renal handling of C3d or its excr...

journal_title：European journal of clinical investigation

authors： Branten AJ,Kock-Jansen M,Klasen IS,Wetzels JF

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Abscess formation is a common bacterial infection and requires an immediate antimicrobial approach for apposite treatment. Delay in patient treatment is usually a common feature, as the bacterial identification of clinical samples is based on the culture, which is a time-consuming exercise. The current study...

journal_title：European journal of clinical investigation

authors： Garg M,Misra MK,Chawla S,Prasad KN,Roy R,Gupta RK

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Recent evidence indicates that remnant lipoprotein particles (RLPs) may play a role in atherosclerosis. Remnant lipoprotein particles have been suggested to be the most atherogenic particles among the triglyceride-rich lipoproteins. In particular, these triglyceride-rich particles were identified as an indep...

journal_title：European journal of clinical investigation

authors： Ossewaarde ME,Dallinga-Thie GM,Bots ML,van der Schouw YT,Rabelink TJ,Grobbee DE,Westerveld HT

更新日期：2003-05-01 00:00:00